Some Products May Appear Restricted
To ensure a smooth and speedy checkout, please log in to your account. Some items may show as restricted simply because you're not logged in.
If you do not have an account, you can register using our registration webform (https://www.avantorsciences.com/us/en/login/register)
If you're still seeing restrictions after logging in, certain products—like chemicals or medical devices—require additional account verification steps to be able to place an order. Some items may additionally require a specific license or customer documentation; additional documentation will be requested for these items prior to shipment.
Specifications
- Antibody type:Primary
- Antigen name:Toll-like Receptor 10
- Antigen symbol:TLR10
- Clonality:Monoclonal
- Clone:3C10C5
- Conjugation:Unconjugated
- Flow cytometry:Yes
- Host:Mouse
- Isotype:IgG1 kappa
- Reactivity:Human
- Form:Liquid
- Antigen synonyms:Toll-like receptor 10|CD290
- Amino acid number:20 to 474
- Storage buffer:PBS containing 0.05% BSA and 0.05% sodium azide.
- Storage temperature:–20 °C
- Shipping temperature:Shipped on Blue Ice
- Immunogen:Synthetic peptide corresponding to aa20-474 (extracellular domain) of human TLR10.
- Purification:purified by Protein G affinity chromatography
- Size:100 µg
- Pk:100 µG
Specifications
About this item
Toll-like receptors (TLRs) are one of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms. TLRs are primary transmembrane proteins of immune cells; they have an extracellular region which contains leucine-rich repeat motifs, and a cytoplasmic tail, which has a Toll/interleukin-1 (IL-1) receptor (TIR) domain. TLRs are pattern recognition receptors (PRRs ) that bind to pathogen-associated molecular patterns (PAMPs). Different TLRs recognize different surface and intracellular components of microorganisms or PAMPS. The interaction between a TLR and a microbial component or PAMP triggers the activation of the innate immune system, as well as the development of acquired immunity. Interaction of PAMPs with different TLRs induces distinct patters of gene expression through signal transduction pathways. TLR signaling occurs through the TIR domains which utilize adaptors such as MyD88, TIRAP, TRIF, and TRAM. NF-kappa-B and JNK pathways are activated leading to the transcription of genes encoding pro-inflammatory cytokines. TLR-10, originally identified from a spleen cDNA library, is on chromosome 4p14 and has been found to be expressed in lung and in B-lymphocytes. TLR10 is thought to be a potential asthma candidate gene because early life innate immune responses to ubiquitous inhaled allergens and PAMPs may influence asthma susceptibility.
Type: Primary
Antigen: TLR10
Clonality: Monoclonal
Clone: 3C10C5
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human