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Specifications
- Antibody type:Primary
- Antigen name:programmed cell death 1
- Antigen symbol:PDCD1
- Clonality:Monoclonal
- Clone:12A7D7
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- ImmunoChemistry:Yes
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Format:Purified Antibody
- Form:Liquid
- Gene ID:5133
- Antigen synonyms:PD-1 Antibody [12A7D7] : PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1
- Storage temperature:PD-1 monoclonal antibody can be stored at -20˚C, stable for one year.
- Concentration:1 mg/mL
- Shipping temperature:4°C
- Immunogen:A ~150 amino acid recombinant protein from near the amino terminus of mouse PD-1.
- Purification:PD-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
- Size:100 μg
- Pk:100 µG
Specifications
About this item
PD-1 Monoclonal Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
PD-1 antibody can be used for detection of PD-1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Type: Primary
Antigen: PDCD1
Clonality: Monoclonal
Clone: 12A7D7
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype:
Reactivity: Human, Mouse, Rat