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Specifications
- Antibody type:Primary
- Antigen name:ORAI calcium release-activated calcium modulator 3
- Antigen symbol:ORAI3
- Clonality:Monoclonal
- Clone:1B4F1
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- Reactivity:Human,Rat
- Western blot:Yes
- Format:Purified Antibody
- Form:Liquid
- Gene ID:93129
- Antigen synonyms:ORAI3 Antibody [1B4F1] : TMEM142C
- Storage temperature:ORAI3 monoclonal antibody can be stored at -20˚C, stable for one year.
- Concentration:1 mg/mL
- Shipping temperature:4°C
- Immunogen:A 19 amino acid synthetic peptide from near the carboxy terminus of human ORAI3.
- Purification:ORAI3 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
- Size:100 μg
- Pk:100 µG
Specifications
About this item
ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.
ORAI3 antibody can be used for detection of ORAI3 by Western blot at 2 μg/mL.
Type: Primary
Antigen: ORAI3
Clonality: Monoclonal
Clone: 1B4F1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype:
Reactivity: Human, Rat