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Specifications
- Pk:25 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Tag sequence:His Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Protein synonyms:High Mobility Group Protein B1
- Protein/peptide name:HMGB1
- Purity:>90% (SDS-PAGE)
- Sequence:24-215
- Formulation:Lyophilized from a concentrated sterile solution containing 50mM Tris-Hcl buffer (pH 8.0) and 100mM NaCl.
Specifications
About this item
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localised innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localised inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
Fusion-Tag: His Tag
This recombinant proteins is for research use only.