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Specifications
- Pk:25 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Tag sequence:His Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Protein synonyms:TXGP1L|ACT35|Tumor Necrosis Factor Receptor Superfamily Member 4|OX40|TNFRSF4
- Protein/peptide name:CD134
- Purity:>97% (SDS-PAGE)
- Sequence:29-216
- Formulation:Lyophilized from a concentrated sterile solution containing 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl.
Specifications
About this item
CD134 (OX40) is a T cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumour necrosis factor receptor superfamily, which also includes the T cell antigen CD27, B cell antigen CD40, FAS antigen and the T cell activation antigen 4-1BB. The human CD134 protein is expressed only on activated CD4+ T blasts, and its ligand has been identified as gp34. Interactions between CD134 and its ligand in vivo are necessary for the differentiation of activated B cells into highly immunoglobulin-producing cells, however not involved in other pathways of antigen-driven differentiation of B cells such as development of memory cells in the germinal centers. In addition, the CD134 and gp34 system directly mediate adhesion of activated T cells to vascular endothelial cells, and contribute to growth stimulation of the virus-infected T cells.
Fusion-Tag: His Tag
This recombinant proteins is for research use only.