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Specifications
- Pk:10 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Tag sequence:His Tag
- Storage conditions:Working aliquots are stable for up to 3 months when stored at −20 °C.
- Protein synonyms:Hairy Homolog|Transcription Factor HES-1|Hairy-like Protein|HRY|bHLHb39|Hairy and Enhancer of Split 1|hHL|Class B Basic Helix-loop-helix Protein 39
- Protein/peptide name:HES1
- Purity:>90% (SDS-PAGE)
- Sequence:2-280
- Formulation:0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
Specifications
About this item
bHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signalling plays both oncogenic and tumour suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukaemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signalling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumour suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.
Fusion-Tag: His Tag
This recombinant proteins is for research use only.