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- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Mouse
- Tag sequence:N-6 His tag
- Storage conditions:Store at −20 °C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Protein synonyms:IDO1|IDO|Indoleamine 2|Indole 2|3-dioxygenase 1|IDO-1|3-dioxygenase|INDO
- Protein/peptide name:IDO
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:47.1 kD
- Sequence:Met1-Pro407
- Formulation:Supplied as a 0.2 um filtered solution of 20mM Sodium Acetate, 150mM NaCl and 20% Glycerol, pH4.5.. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution toPTTLGTIHSPEDVIKALADHHHHHHHHHE
Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. This protein is normally expressed in the dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumour cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumour cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumour associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterised by pathological immune suppression.
Fusion-Tag: N-6 His tag
This recombinant protein can be used for biological assays. For research use only.