Mouse recombinant ectodysplasin receptor

50 µG

Catalog # PRSI92-570

Supplier: ProSci Inc.

Catalog # PRSI92-570

Supplier: ProSci Inc.

CAS Number:

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CAS Number:

Price

£452.00

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Product Details & Documents

Ectodysplasin A receptor (EDAR) is a type I transmembrane protein of the TNF- alpha receptor superfamily which plays a key role in ectodermal differentiation. EDAR was encoded by the mouse down less gene and defective in human dominant and recessive forms of autosomal hypo hidrotic ectodermal dysplasia (EDA) syndrome. The extracellular domain of EDAR contains 14 cysteine residues, six of which approximate the TNFRSF cysteine-rich region, the cytoplasmic domain contains a region with homology to the death domains found in other TNFRSF members. EDAR has been suggested to be an early and important promoter of placode development in all ectodermal organs, such as uch as hair follicles, teeth and sweat glands. EDA-A1, the A1 isoform of EDA, is the EDAR ligand. EDA and EDA are implicated in appendage development by the cloning of a gene underlying hypo hidrotic ectodermal dysplasia (HED) in mouse and human. HED is Characterised by agenesis or malformation of ectoderm-derived appendages, such as teeth, sweat glands and hair follicles, while the skin itself develops normally.

Fusion-Tag: C-Fc tag

This recombinant protein can be used for biological assays. For research use only.

Documents

Datasheet

75791-702.pdf

About ProSci

Specifications

Pk:
50 µG
Cat. No.:
PRSI92-570
Protein/peptide type:
Recombinant
Protein/peptide name:
Ectodysplasin Receptor
Storage conditions:
Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Protein synonyms:
EDAR|Anhidrotic ectodysplasin receptor 1|Tumor necrosis factor receptor superfamily member EDAR|Downless|Ectodysplasin-A receptor|Ectodermal dysplasia receptor
Purity:
> 95% as determined by reducing SDS-PAGE
Tag sequence:
C-Fc tag
Sequence:
Glu27-Ile189
Species:
Mouse
Molecular weight:
44.7 kD

Specifications

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