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Human recombinant BIRC5 (from E. coli)
Human recombinant BIRC5 (from E. coli)
Catalog # PRSI92-047
Supplier:  ProSci Inc.
CAS Number:  
Human recombinant BIRC5 (from E. coli)
Catalog # PRSI92-047
Supplier:  ProSci Inc.
CAS Number:  

Specifications

  • Pk:
    50 µG
  • Protein/peptide type:
    Recombinant
  • Source:
    E. coli
  • Species:
    Human
  • Storage conditions:
    Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
  • Protein synonyms:
    Apoptosis Inhibitor 4|IAP4|Apoptosis Inhibitor Survivin|API4|Baculoviral IAP Repeat-Containing Protein 5|BIRC5
  • Protein/peptide name:
    BIRC5
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Molecular weight:
    20.4 kD
  • Sequence:
    Met1-Asp142
  • Formulation:
    Lyophilized from a 0.2 um filtered solution of 20mM Tris, 0.1M NaCl, pH 7.5. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested applications:
    Bioassay

Specifications

About this item

Baculoviral IAP Repeat-Containing Protein 5 (BIRC5) belongs to the IAP family. BIRC5 exists as a homodimer in the apo state and as a monomer in the CPC-bound state. BIRC5 contains one BIR repeat and is expressed only in fetal kidney and liver, and to lesser extent, lung and brain. BIRC5 functions as a multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. BIRC5 is also a component of a chromosome passage protein complex (CPC), which is essential for chromosome alignment and segregation during mitosis and cytokinesis. BIRC5 acts as an important regulator of the localization of this complex.

  • This recombinant protein can be used for biological assays. For research use only.