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Specifications
- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Tag sequence:N-GST tag
- Storage conditions:Store at −20 °C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Gene ID:3093
- Protein synonyms:Huntingtin-Interacting Protein 2|Ubiquitin Carrier Protein|E2-25K|Ubiquitin-Protein Ligase|HIP2|Ubiquitin-Conjugating Enzyme E2-25 kDa|UBE2K|LIG|Ubiquitin-Conjugating Enzyme E2 K|Ubiquitin-Conjugating Enzyme E2-25K|HIP-2|Ubiquitin-Conjugating Enzyme E2(25K)
- Protein/peptide name:UBE2K
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:48.7 kD
- Sequence:Met1-Asn200
- Formulation:Supplied as a 0.2 um filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested applications:For Biological assays
Specifications
About this item
Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with huntingtin, and MHC-heavy chain proteins.
- This recombinant protein can be used for biological assays. For research use only.
Fusion-Tag: N-GST tag