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- Pk:100 µG
- Protein/peptide type:Recombinant
- Source:HEK293 cells
- Species:Human
- Biological activity:Measured by its binding ability in a functional ELISA. Immobilized human TNFRSF10B at 10μg/ml ( 100μl/well ) can bind biotinylated TNFSF10 with a linear range of 0. 375 - 10 ng/mL.
- Protein synonyms:TRAILR2|TRAIL-R2|CD262|TRICK2|KILLER|TRICKB|ZTNFR9|TNFRSF10B|DR5
- Protein/peptide name:Dr51
- Purity:>95% as determined by SDS-PAGE.
- Molecular weight:15.1 kDa
- Formulation:Lyophilized, PBS, pH7.4
- Tested applications:Western Blot
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor.
The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.