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Specifications
- Pk:25 µG
- Protein/peptide type:Recombinant
- Source:HEK293 cells
- Species:Human
- Biological activity:Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca - RPKPVE - Nval - WRK(Dnp) - NH2.
- Protein synonyms:Glia-derived nexin|PI7|SERPINE2|GDN|SerpinE2|Peptidase inhibitor 7|PN-1|Serpin E2|PI-7|Protease nexin 1
- Protein/peptide name:Serpin E2
- Purity:>92% as determined by SDS-PAGE.
- Molecular weight:42.7 kDa
- Formulation:Lyophilized, 20 mM NaAc, 100 mM NaCl, PH6.5
- Tested applications:Western Blot
Specifications
About this item
SERPINE2 is also known as Glia-derived nexin (GDN), Peptidase inhibitor 7 (PI7), Protease nexin 1(PN1). SERPINE2 is a secreted glycoprotein which belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). PAI-1 / GDN is also implicated in adipose tissue development. It suggests that PAI-1 inhibitors serve in the control of atherothrombosis. Defects in Serpin E1 / PN1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma.