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Specifications
- Pk:10 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Biological activity:Biological activity was determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/mL. Endotoxin level is less than 0.1 ng per μg of BMP-4 (1EU/μg).
- Protein synonyms:BMP2B1|DVR4|MCOPS6|BMP-4|ZYME|OFC11|BMP2B|Bone morphogenetic protein 4|Bone morphogenetic protein 2B
- Protein/peptide name:BMP4
- Purity:>98%
- Formulation:Lyophilized
Specifications
About this item
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.
- Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein. Both ProSci’s E.coli derived BMP-4 and PeproTech’s E.coli derived murine BMP-4 are fully active homodimeric protein consisting of two 106 amino acid subunits which correspond to amino acids 303-408 of the full length BMP-4 precursor.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.