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Specifications
- Pk:10 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Biological activity:Determined by its ability to chemoattract human peripheral blood lymphocytes using a concentration range of 50.0-1000.0 ng/mL.
- Protein synonyms:NIL16|Lymphocyte chemoattractant factor|prIL-16|IL-16|PRIL16|Pro-interleukin-16|LCF
- Protein/peptide name:IL16
- Purity:>98%
- Formulation:Lyophilized
- Tested applications:Western Blot, ELISA
Specifications
About this item
IL-16 was initially identified as a chemotactic cytokine (1), but is now known to possess a wide range of activities. Later studies have more fully characterized IL-16 as an immunomodulatory cytokine that contributes to the regulatory process of CD4+ T cell recruitment and activation at sites of inflammation in association with asthma and several autoimmune diseases (2). The precursor of IL-16 (pro-IL-16) is thought to be cleaved towards the C-terminal region by Caspase-3, releasing a 20 kDa active form that binds to and signals through CD4 (3,4). Besides acting as a chemotactic cytokine, IL-16 is thought to also be involved in the regulation of T cell proliferation (5) and multiple infectious, immune-mediated, and autoimmune inflammatory disorders including irritable bowel syndrome, systemic lupus erythematosus, and neurodegenerative disorders (6). At least two isoforms of IL-16 are known to exist; the longer isoform (also known as NIL-16) is detected only in neurons of the cerebellum and hippocampus (7). This recombinant protein fragment is derrived from this longer isoform.
- This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
1X PBS containing 0.1% SDS
Store in working aliquots at -80°C. Avoid freeze/thaw cycles.