Specifications
- Pk:25 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Biological activity:Assay #1: The ED50 as determined by the dose-dependent stimulation of IL-8 production by human PBMC is less than 10 ng/mL.
Assay #2: TWEAK weakly induces the death of HT29 cells when cultured in the presence of IFN-gamma. The ED50 for this effect is between 30-45 ng/mL. - Gene ID:8742
- Protein synonyms:UNQ181/PRO207|APO3L|APO3 ligand|TWEAK|Tumor necrosis factor ligand superfamily member 12|DR3LG
- Protein/peptide name:TWEAK
- Purity:>98%
- Formulation:Lyophilized
Specifications
About this item
TWEAK belongs to the TNF family of ligands and signals through TWEAKR also known as TNFRSF12A. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK has the ability to induce NFkB activation and chemokine secretion, and to exert an apoptotic activity in certain cells, such as HT-29 human adenocarcinoma cells when cultured in the presence of IFN-γ. TWEAK also promotes proliferation and migration of endothelial cells. Recombinant human TWEAK is a soluble 17.0 kDa polypeptide (154 amino acid residues) comprising the TNF homologous region of TWEAK and is generated by proteolytic processing of the full length membrane anchored TWEAK protein.
- Store in working aliquots at -20°C. Avoid freeze/thaw cycles.