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Specifications
- Antigen name:Myelin basic protein
- Antigen symbol:MBP
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:Myelin A1 protein|MBP|Myelin membrane encephalitogenic protein|Myelin basic protein
- Concentration:1 mg/mL
- Immunogen:MBP (myelin basic protein) antibody was raised against a peptide sequence around aa.291~295 (G-G-R-D-S) derived from Human MBP.
- Size:100 µg
- Pk:100 µG
Specifications
About this item
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Western Blot: 1:500~1:1000
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type:
Antigen: MBP
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat