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Specifications
- Antigen name:Mitogen-Activated Protein Kinase Kinase 4
- Antigen symbol:MAP2K4
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:MKK4|SAPKK-1|PRKMK4|SAPKK1|MAPKK4|SERK1|SKK1|MEK4|JNKK1|JNKK|SEK1
- Concentration:1 mg/mL
- Immunogen:MAP2K4 antibody was raised against a peptide sequence around aa.352~356 (E-S-K-R-P) derived from Human MAP2K4. .
- Size:100 µg
- Pk:100 µG
Specifications
About this item
SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines. Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop. Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction.
Western Blot: 1:500~1:1000
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type:
Antigen: MAP2K4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat