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Specifications
- Antigen name:Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5
- Antigen symbol:RPS6KA5
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:MSK1|S6K-alpha-5|Ribosomal protein S6 kinase alpha-5|Nuclear mitogen- and stress-activated protein kinase 1|90 kDa ribosomal protein S6 kinase 5|RLPK|MSPK1|RSK-like protein kinase
- Concentration:1 mg/mL
- Immunogen:MSK1 (Ab-376) antibody was raised against a peptide sequence around aa.374~378 (G-Y-S-F-V) derived from Human MSK1.
- Size:100 µg
- Pk:100 µG
Specifications
About this item
Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
Western Blot: 1:500~1:1000
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type:
Antigen: RPS6KA5
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat