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Specifications
- Antigen name:Integrin Alpha 4
- Antigen symbol:ITGA4
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Reactivity:Hamster,Bat,Pig,Rabbit,Monkey,Gibbon,Gorilla,Human,Dog,Rat,Mouse
- Form:Liquid
- Antigen synonyms:CD49D|CD49 antigen-like family member D|IA4|Integrin alpha-4|Integrin alpha 4
- Immunogen:Integrin alpha 4 antibody was raised against a peptide located in the C-Terminal domain of Integrin alpha 4 (Human).
- Tested applications:Immunoaffinity Chromatography
- Size:50 µg
- Pk:50 µG
Specifications
About this item
ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling.
PBS, 0.1% sodium azide.
Aliquot and store at -80°C. Avoid multiple freeze-thaw cycles.
Type:
Antigen: ITGA4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Bat, Dog, Gibbon, Gorilla, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat