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- Antigen name:Discoidin Domain receptor tyrosine kinase 2
- Antigen symbol:DDR2
- Clonality:Monoclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- ImmunoChemistry:Yes
- Isotype:IgG2a
- Reactivity:Human
- Western blot:Yes
- Antigen synonyms:Receptor protein-tyrosine kinase TKT|receptor-related 3|Neurotrophic tyrosine kinase|NTRKR3|DDR2|Discoidin domain receptor 2|TKT|Tyrosine-protein kinase TYRO 10
- Immunogen:Ni-NTA purified truncated recombinant DDR2-Trx expressed in E. Coli strain BL21 (DE3).
- Size:100 µl
- Pk:100 µl
DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.
Ascitic fluid containing 0.03% sodium azide.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type:
Antigen: DDR2
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human