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- Antibody type:Primary
- Antigen name:ADAM Metallopeptidase Domain 17
- Antigen symbol:ADAM17
- Clonality:Polyclonal
- Conjugation:PE (Phycoerythrin)
- Flow cytometry:Yes
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:6868
- Antigen synonyms:TACE|Snake venom-like protease|ADAM18|CSVP|TNF-alpha-converting enzyme|CD156B|CD156b antigen|TNF-alpha convertase|A disintegrin and metalloproteinase domain 17|NISBD|NISBD1
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:216-266/824
- Purification:Purified by Protein A
- Pk:100 µl
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Recommended Dilutions: Flow Cytometry: 1:20-100
Type: Primary
Antigen: ADAM17
Clonality: Polyclonal
Clone:
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat