Human Recombinant Cathepsin F (from Insect cells)

About this item

Recombinant glycosylated procathepsin F cloned from human cDNA (NM_003793), expressed in insect cells, and purified as the active form of the enzyme. Cathepsin F, a member of the papain family of lysosomal cysteine proteases, acts upon proteins such as MHC Class II-associated invariant chain and ApoB-100.

Produced in insect cells (secreted) as untagged proenzyme; activated during purification
Highly active
Purified by multi-step chromatography (SDS-PAGE)
Useful tool to study enzyme kinetics, cleave target substrates, and screen for inhibitors

It is a lysosomal protease expressed in numerous tissues, notably brain and macrophages. It functions in the immune system and is implicated in disease states such as atherosclerosis, cancer, and angiogenesis.

It has a liquid formulation in 20 mM NaOAc at pH 5,0, containing 2,5 mM EDTA, 250 mM sodium chloride and 20 mM L-cysteine.

One unit hydrolyses 1 µmol Z-Phe-Arg-AMC substrate (OMNICATHEPSIN® Fluorogenic substrate) per min. at 37 °C.

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