Anti-ZNF131 Rabbit Polyclonal Antibody

Catalog # BOSSBS-12358R

Supplier: Bioss

Catalog # BOSSBS-12358R

Supplier: Bioss

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Specifications

Antibody type:
Primary
Antigen name:
Zinc Finger Protein 131
Antigen symbol:
ZNF131
Clonality:
Polyclonal
Conjugation:
Unconjugated
Host:
Rabbit
ImmunoChemistry:
Yes
Isotype:
IgG
Reactivity:
Human
Western blot:
Yes
Form:
liquid
Gene ID:
7690
Antigen synonyms:
pHZ-10|ZBTB35
Storage buffer:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0,09% sodium azide. Store at -20°C for 12 months.
Concentration:
1 ug/ul
Shipping temperature:
4 °C
Purification:
Purified by Protein A.
Size:
100 μg
Pk:
100 µl

Specifications

About this item

YKL-39 is a 390 amino acid cartilage protein that belongs to the chitinase family of chitin-fragmenting hydrolases. Highly expressed in chondrocytes (cartilage cells) and synoviocytes (fibroblastic cells that line joint cavities), YKL-39 binds glycan structures with high affinity. Although related to bacterial chitinases, YKL-39 lacks the characteristic glutamate active site and, thus, does not have enzymatic chitinase activity. Patients affected with rheumatoid arthritis (RA) have autoimmunity against YKL-39, suggesting that YKL-39 is involved in osteoarthritic and/or rheumatoid joint disease. Additionally, YKL-39 is upregulated in early degenerative cartilage diseases (such as RA) and may be a marker of chondrocyte activation in these autoimmune conditions.