38381 Results for: "Midecamycin&pageNo=8"

Supplier: Biotium

HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

Supplier: Jallatte

SHOE JALLUNE SAS ESD S3 SI SRC S.38 1 * 1 PAIR

Supplier: Sampling Systems

These PowderThief samplers are suitable for sampling free flowing powders and granules.

Supplier: Apollo Scientific

Isoquinoline-8-amine 98%

Supplier: Thermo Fisher Scientific

4-Tritylphenol ≥98%

Supplier: Thermo Fisher Scientific

3,5-Dimethoxyphenol ≥98%

Supplier: Thermo Fisher Scientific

2-Amino-1,3,4-thiadiazole ≥98%

Supplier: Thermo Fisher Scientific

Octadecyltriethoxysilane 98% (n-isomer ≥ 85%)

Supplier: Thermo Fisher Scientific

1,7-Heptanediol ≥98%

Supplier: Thermo Fisher Scientific

2',6'-Dichloroacetophenone ≥98%

Supplier: Thermo Fisher Scientific

4-Hydroxy-1-methylpiperidine ≥98%

Supplier: Thermo Fisher Scientific

6-Nitro-o-toluic acid ≥98%

Supplier: Thermo Fisher Scientific

2-Chloro-5-nitrobenzotrifluoride ≥98%

Supplier: Thermo Fisher Scientific

2,6-Dichloro-3-(trifluoromethyl)pyridine ≥98%

Supplier: Thermo Fisher Scientific

(S)-(+)-Methyl-3-hydroxybutyrate ≥98%

Supplier: Thermo Fisher Scientific

Methyl-2-amino-5-chlorobenzoate ≥98%

Supplier: Thermo Fisher Scientific

2-Bromo-6-methylpyridine ≥98%

Supplier: Thermo Fisher Scientific

Direct red 80

Supplier: Thermo Fisher Scientific

4-Ethylpyrocatechol ≥98%

Supplier: Thermo Fisher Scientific

4-Chloro-2,6-xylidine ≥98%

Supplier: Thermo Fisher Scientific

ω-Bromo-2-nitroacetophenone ≥98%

Supplier: Thermo Fisher Scientific

tert-Butyl propiolate ≥98%

Supplier: Thermo Fisher Scientific

N-(tert-Butoxycarbonyl)-L-tert-leucine 98%

Supplier: Thermo Fisher Scientific

3-Chloro-5-fluorophenol ≥98%

Supplier: Thermo Fisher Scientific

4-Fluoro-3-nitrobenzaldehyde ≥98%

Supplier: Thermo Fisher Scientific

2-Bromo-4-fluoro-6-(trifluoromethyl)aniline ≥98%

Supplier: Thermo Fisher Scientific

4-Methyl-2-(trifluoromethyl)benzonitrile 98%

Supplier: Thermo Fisher Scientific

3-Fluoro-4-methoxybenzyl chloride 98%

Supplier: Thermo Fisher Scientific

4-Hydroxy-3-(trifluoromethyl)benzonitrile ≥98%

Supplier: Thermo Fisher Scientific

Methyl-3-bromo-5-fluorobenzoate ≥98%