33258 Results for: "Eosin+Y&pageNo=68"

Supplier: Thermo Fisher Scientific

Titanium ≥99.7% (metals basis), rods, Ø 6.4 mm (0.25 in)

Supplier: Abcam

Rabbit monoclonal [EPR20936-67] to CXCL15 - BSA and Azide free (Capture).

Supplier: Bioss

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF206 (zinc finger protein 206), also known as ZSCAN10 (zinc finger and SCAN domain containing 10), is a 725 amino acid protein that contains one SCAN box domain and 14 C2H2-type zinc fingers. Localized to the nucleus, ZNF206 is thought to play a role in transcriptional regulation events. The gene encoding ZNF206 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Supplier: Bioss

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidised low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Supplier: Bioss

Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. Oxyntomodulin significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.

Supplier: Bioss

The RAD23 gene of Saccharomyces cerevisiae is required for excision-repair of UV damaged DNA (1). RAD23 resembles the other DNA repair genes, RAD2, RAD6, RAD7, RAD18, and RAD54, all of which also exhibit increased transcription in response to DNA damage and during meiosis (2). RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function (3). RAD23 bears a ubiquitin-like domain at its amino terminus and this ubiquitin-like domain affects protein function in a nonproteolytic manner (3). Rad23 is a highly conserved protein involved in nucleotide excision repair (NER) that associates with the proteasome via its amino-terminus (4). Its carboxy-terminal ubiquitin-associated domain is evolutionarily conserved from yeast to humans (4). In addition to a role in DNA repair events in yeast, several lines of evidence indicate that the Rad23 protein may regulate the activity of the 26 S proteasome (5).

Supplier: Bioss

The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch Signalling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

Supplier: Bioss

Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993[PubMed 8262133]).[supplied by OMIM].

Supplier: Bioss

Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilises the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.

Supplier: Abcam

Rabbit monoclonal [EPR25674-65] to c-Myc - BSA and Azide free (Capture).

Supplier: Abcam

Rabbit monoclonal [EPR25387-48] to Stargazin - BSA and Azide free.

Supplier: Abcam

Mouse monoclonal [MEM-48] to CD18.

Supplier: Abcam

Rabbit monoclonal [EPR23690A-48] to IDO-2 - BSA and Azide free (Capture).

Supplier: Abcam

Rabbit monoclonal [EPR24018-18] to FGL1 - BSA and Azide free (Detector).

Supplier: Abcam

Rabbit monoclonal [062] to L-Kynurenine Hydrolase - BSA and Azide free.

Supplier: TCI

4,8-Bis-n-octyloxybenzo[1,2-b:4,5-b']dithiophene ≥98.0% (by GC)

Supplier: Abcam

Rabbit monoclonal [EPR4466-48] to FOXA2 - BSA and Azide free (Capture).

Supplier: Abcam

Rabbit monoclonal [EPR13174-61] to FUBP3 - BSA and Azide free.

Supplier: Abcam

Rabbit monoclonal [EPR13233-60] to ARHGAP25 - BSA and Azide free.

Supplier: Abcam

Rabbit monoclonal [EPR15295-58] to PON2 - BSA and Azide free.

Supplier: Abcam

Rabbit monoclonal [EPR3360(2)] to Somatostatin 28 - BSA and Azide free.

Supplier: Abcam

Rabbit monoclonal [EPR20415-67] to Securin - BSA and Azide free (Detector).

Supplier: Abcam

Rabbit monoclonal [EPR21830-61] to Vaspin - BSA and Azide free (Capture).

Supplier: Abcam

Rabbit monoclonal [EPR21962-58] to CD86 - BSA and Azide free (Capture).

Supplier: Abcam

Rabbit monoclonal [EPR22394-28] to CD59 - BSA and Azide free (Capture).

Supplier: Abcam

Rabbit monoclonal [EPR22973-65] to RANKL - BSA and Azide free (Capture).

Supplier: Abcam

Rabbit monoclonal [EPR20131-28] to Thrombin - BSA and Azide free (Capture).

Supplier: Abcam

Rabbit monoclonal [EPR18014-69] to IGFBP6 - BSA and Azide free (Capture).

Supplier: Abcam

Rabbit monoclonal [EPR17017-28] to MMP3 - BSA and Azide free (Capture).

Supplier: Abcam

Rabbit monoclonal [EPR20672-18] to FABP4 - BSA and Azide free (Capture).