5303 Results for: "Enzo Life Sciences"

Supplier: ENZO LIFE SCIENCES

From cytomegalovirus, strain AD169. Inactivated by 0.2% Triton X-100.

Supplier: ENZO LIFE SCIENCES

GABA_A receptor antagonist.

Supplier: ENZO LIFE SCIENCES

Serotonin hydrochloride

Supplier: ENZO LIFE SCIENCES

Glucocorticoid receptor modulator.

Supplier: ENZO LIFE SCIENCES

ATP-sensitive K⁺ channel activator.

Supplier: ENZO LIFE SCIENCES

Specific, competitive and reversible acetylcholinesterase inhibitor. Alzheimer's disease therapeutic.

Supplier: ENZO LIFE SCIENCES

K⁺ channel activator. Antihypertensive.

Supplier: ENZO LIFE SCIENCES

Host: Mouse, Isotype: IgG1

Supplier: ENZO LIFE SCIENCES

Host: Rat, Isotype: IgG2a

Supplier: ENZO LIFE SCIENCES

Host: Mouse, Isotype: IgG1

Supplier: ENZO LIFE SCIENCES

Host: Rat, Isotype: IgM

Supplier: ENZO LIFE SCIENCES

Host: Rat, Isotype: IgG2a

Supplier: ENZO LIFE SCIENCES

Host: Rat, Isotype: IgG2a

Supplier: ENZO LIFE SCIENCES

Host: Mouse, Isotype: IgG1

Supplier: ENZO LIFE SCIENCES

Human recombinant IGF-I (from E. coli)

Supplier: ENZO LIFE SCIENCES

Cyclic AMP (cAMP) is one of the most important second messenger involved as a modulator of physiological processes. A number of hormones are known to activate cAMP through the action of the enzyme Adenylate cyclase which converts ATP to cAMP. cAMP has been shown to be involved in the cardiovascular and nervous systems, immune mechanisms, cell growth and differentiation, and general metabolism.

Supplier: ENZO LIFE SCIENCES

Mouse-HRP/rabbit-AP IHC is a biotin-free one-step detection system suitable for demonstrating antigens in formalin-fixed paraffin-embedded tissues and cryostat sections.

Supplier: ENZO LIFE SCIENCES

Immunohistochemistry (mouse/rabbit-HRP) detection reagent is a non-biotin one-step detection reagent.

Supplier: ENZO LIFE SCIENCES

The creatinine colorimetric detection kit utilises a single step liquid detection reagent that is safer and less time consuming than other assay methods.

Supplier: ENZO LIFE SCIENCES

TRAIL decoy receptors (DcR1, DcR2, and osteoprotegerin/OPG) completely or partially lack the signaling death domain, and/or are secreted from cells and unable to transmit intracellular signals.

Supplier: ENZO LIFE SCIENCES

ST2 is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs).

Supplier: ENZO LIFE SCIENCES

CLIP (class II-associated invariant chain peptide) is an important peptide in the MHC-II antigen processing pathway, formed by the enzymatic cleavage of amino acids 81-104 from the invariant chain. During MHC-II synthesis in the ER and transport to endocytic vesicles, the antigen binding site of MHC-II is obstructed by the presence of the invariant chain. As the MHC-II complex moves through the Golgi, the invariant chain is degraded, leaving the CLIP fragment in the MHC-II peptide binding groove. CLIP is eventually displaced by the loading of antigenic peptides, followed by presentation on the APC cell surface to CD4+ T-cells.

Supplier: ENZO LIFE SCIENCES

Mcl-1 is a member of the Bcl-2 family that possesses anti-apoptotic activity. Mcl-1 is an immediate-early gene activated by the GMCSF as well as IL-3 signaling pathways and plays an important role in the viability response of these cytokines. Similar to all Bcl-2 family members, Mcl-1 contains BH1, BH2, and BH3 domains; however, unlike other members of this family, Mcl-1 has an extended N-terminal domain rich in PEST sequences, which probably accounts for the short half-life of this protein.

Supplier: ENZO LIFE SCIENCES

Bim is a critical regulator of lymphocyte homeostasis, acts as a barrier against autoimmune disease and is necessary for the apoptotic response to certain stress signals.

Supplier: ENZO LIFE SCIENCES

Actin is one of the major proteins (~42 kDa) of the cytoskeleton. It regulates contractile potential in muscle tissues and helps to control the shape as well as the motility of non-muscle cells. Actin is expressed in all eukaryotic cells which makes it a useful loading control in Western blotting experiments. In higher eukaryotes, there are six isoforms of actin: Three alpha-actins (α-skeletal, α-cardiac, α-smooth muscle), one β-actin (β-non-muscle) and two γ-actins (γ-smooth muscle and γ-non-muscle). Actin isoforms show >90% overall sequence homology.

Supplier: ENZO LIFE SCIENCES

The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or ?executioner? caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

Supplier: ENZO LIFE SCIENCES

MyD88 (Myeloid differentiation primary response gene 88) is a general adapter protein for the Toll/IL-1R family of receptors that have been shown to induce growth arrest, terminal differentiation, and apoptosis.

Supplier: ENZO LIFE SCIENCES

MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs recognize different pathogen-associated molecular patterns, thereby linking the innate and adaptive immune responses.

Supplier: ENZO LIFE SCIENCES

Bnip3L/Bnip3alpha/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. In particular, Bnip3L interacts with and overcomes the suppression of apoptosis mediated by Bcl-2 and Bcl-xL.

Supplier: ENZO LIFE SCIENCES

The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.