62260 Results for: "Bicyclo[1.1.1]pentane-1,3-diamine+dihydrochloride&pageNo=50"

Supplier: Epredia

Microslide Superfrost 90° CC yellow glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide Superfrost 90° CC blue glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: MACRON AVANTOR BRAND

L-Arginine hydrochloride 98.5-101.5% (dried basis) USP, FCC, Multi-Compendial, Macron Fine Chemicals™

Supplier: ProSci Inc.

The Fas is also known as FAS receptor (FasR), apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6). is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two apoptosis pathways, the other being the mitochondrial pathway. FasR is located on chromosome 10 in humans and 19 in mice. Similar sequences related by evolution (orthologs) are found in most mammals. Fas forms the death-inducing signaling complex (DISC) upon ligand binding. Membrane-anchored Fas ligand trimer on the surface of an adjacent cell causes trimerization of Fas receptor. This event is also mimicked by binding of an agonistic Fas antibody, though some evidence suggests that the apoptotic signal induced by the antibody is unreliable in the study of Fas signaling. To this end, several clever ways of trimerizing the antibody for in vitro research have been employed.Upon ensuing death domain (DD) aggregation, the receptor complex is internalized via the cellular endosomal machinery. This allows the adaptor molecule FADD to bind the death domain of Fas through its own death domain. Recently, Fas has also been shown to promote tumor growth, since during tumor progression, it is frequently downregulated or cells are rendered apoptosis resistant. Cancer cells in general, regardless of their Fas apoptosis sensitivity, depend on constitutive activity of Fas. This is stimulated by cancer-produced Fas ligand for optimal growth.

Supplier: ProSci Inc.

tumour Necrosis Factor- alpha (TNF- alpha) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF- alpha while cells that express CD8 secrete little or no TNF- alpha. Synthesis of TNF- alpha can be induced by many different stimuli including interferons, IL2, and GM-CSF. The clinical use of the potent anti-tumour activity of TNF- alpha has been limited by the proinflammatory side effects such as fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF- alpha mutants with low systemic toxicity has been of intense pharmacological interest. Human TNF- alpha that binds to murine TNF-R55 but not murine TNF-R7, exhibits retained anti-tumour activity and reduced systemic toxicity in mice compared with murine TNF- alpha, which binds to both murine TNF receptors. Based on these results, many TNF- alpha mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumour cell lines in vitro and have exhibited lower systemic toxicity in vivo. Recombinant Human TNF- alpha High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8, Lys9, Arg10 and Phe157. This mutant form has been shown to have increased activity with less inflammatory side effects in vivo.

Supplier: VICI

C75TH-1673EUHB - 3 mpos trapping-path, u-electric, USB 1/16*.25mm, 50C/10000psi liq, N60C/E3 Electric Universal Actuator Serial interface: USB 1 * 1 items

Supplier: Hospidex

Microsyringe 50µl GC standard with glass handle and interchangeable needle 1 * 1 items

Supplier: witeg Labortechnik

HOMOGENIZER HG-15D-SET 1 * 1 items

Supplier: Hospidex

Microsyringe 50µl GC standard with glass handle and fixed needle 1 * 1 items

Supplier: HAMILTON ROBOTICS

50ul core tips clear stack, 5x4 stacks / 11520 1 * 11.520 items

Supplier: ProSci Inc.

Human EN-RAGE belongs to the S100/calgranulin superfamily. There are at least 21 different S100 proteins and the protein is 100% soluble in ammonium sulfate at neutral pH. S100 proteins play a role in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response.Human EN-RAGE is characterized by two EF-hand calcium-binding motifs, zinc- and copper-binding protein.S100A12 is a disulfide-linked homodimer and the interface between the two subunits is composed mostly of hydrophobic residues.Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. EN-RAGE acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also acts as a monocyte and mast cell chemoattractant. Moreover, it can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. It can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+from their active sites.

Supplier: Thermo Orion

These bench top meters with conductivity module meet most challenging applications for pH, ion concentration, mV, ORP and temperature. The meters offer interchangeable measurement modules that allow multiple users to customise four separate channels to meet their specific requirements.

Supplier: SELECTA

FIXED ROTOR 6 TUBES 50ML 1 * 1 items

Supplier: Amarell

Metal ferrules, DIN 12787 mounted on Viscometer therm., Vogel-Ossag 1 * 1 items

Supplier: Copan

Rapid DNA testing made portable. MicroFLOQ® is an innovative DNA collection tool featuring a micro flocked swab-head co-developed* by French Gendarmerie Forensic Research Institute (IRCGN™) and Copan.

Supplier: OMEGA BIO-TEK

Selected protease digestion releases microgram amounts of DNA from FFPE samples.

Supplier: Amarell

Thermometer similar to IP 76 C, solid stem, white backed, 10+55:0,5°C, capillary tube specially coated inside, with non-wetting blu e special liquid, durable pigment, null

Supplier: G-Biosciences

COLUMN, 2 ADJ END, 50x460 1 * 1 items

Supplier: Thies Clima

SCHREIBSTREIFEN 0-50C 0-100 31 TAGE 1 * 100 ST

Supplier: Thermo Fisher Scientific

PISTON 1 * 1 items

Supplier: Amarell

Thermometer similar to BS 1365, SB55C/total, 45+55:0,1°C, solid stem, white backed, capillary tube specially coated inside, with no n-wetting blue special liquid, 235mm long, total immersion, durable pigment, null

Supplier: Amarell

Thermometer similar to BS 593, F75C/100, 24+78:0,2°C, solid stem, white backed, capillary tube specially coated inside, with non-we tting blue special liquid, 395mm long, 100mm immersion, durable pigment null

Supplier: Amarell

Thermometer similar to S.T.P.T.C. T 17d, solid stem, white backed, 39,5+70,5:0,1°C, length 400mm, imm. 100mm, capillary tube specia lly coated inside, with non-wetting blue special liquid, durable pigment, null

Supplier: Amarell

Thermometer similar to IP Abel Water-Bath Celsius, solid stem, white backed, 32+88:0,5°C, capillary tube specially coated inside, w ith non-wetting blue special liquid, sdurable pigment, null

Supplier: Amarell

Thermometer similar to IP Abel Oil Cup Celsius, solid stem, white backed, 10+65:0,5°C, capillary tube specially coated inside, with non-wetting blue special liquid, durable pigment, null

Supplier: Merck

BacterialXpress™ Nucleic acid extraction kit is intended for the purification of bacterial DNA from plasma, serum, cerebral spinal fluid, amniotic fluid, tissue, bone marrow, and cell culture.

Supplier: Amarell

Density hydrometer, 1,060-1,120:0,001g/cm , ref. temp. 20C, with therm., 350mm long, special liquid 1 * 1 items

Supplier: Amarell

Thermometer similar to BS 1900, SR6/51C, 33+51:0,05°C, length 480mm, total immersion, solid stem, white backed, capillary tube spec ially coated inside, with non-wetting blue special liquid, with ice point scale, null

Supplier: Amarell

Soil therm., British type, similar specification, right angle, -7+38:0,5°C, solid stem, white backed, red special liquid, round bulb with diameter 11,5-14,0mm, built-in length 75mm (MK2B), lower part 100mm, suitable for government verification 1 * 1 items

Supplier: ROETZMEIER SICHERH BEHAELTER

Plug-in funnel straight (for all safety barrels) Adjustment: screwing to provide overfill 1 * 1 items