Anti-PDGF B Rabbit Monoclonal Antibody [clone: EPR20620-36]
Supplier: Abcam
Rabbit monoclonal [EPR20620-36] to PDGF B - BSA and Azide free (Detector).
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Anti-NPHS2 Rabbit Monoclonal Antibody [clone: EPR22203-301]
Supplier: Abcam
Rabbit monoclonal [EPR22203-301] to NPHS2 - BSA and Azide free (Detector).
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Anti-MEF2D Rabbit Monoclonal Antibody [clone: EPR24993-10]
Supplier: Abcam
Rabbit monoclonal [EPR24993-10] to MEF2D - BSA and Azide free.
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Anti-ICAM3 Rabbit Monoclonal Antibody [clone: EPR22890-230]
Supplier: Abcam
Rabbit monoclonal [EPR22890-230] to ICAM3 - BSA and Azide free (Capture).
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Anti-PSGL-1 Rabbit Monoclonal Antibody [clone: EPR22504-32]
Supplier: Abcam
Rabbit monoclonal [EPR22504-32] to PSGL-1 - BSA and Azide free (Capture).
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Anti-MMP12 Rabbit Monoclonal Antibody [clone: EPR22132-32]
Supplier: Abcam
Rabbit monoclonal [EPR22132-32] to MMP12 - BSA and Azide free (Detector).
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3,3'-Diethyloxadicarbocyanine iodide (DODC) ≥98.0% (by total nitrogen basis)
Supplier: TCI
3,3'-Diethyloxadicarbocyanine iodide (DODC) ≥98.0% (by total nitrogen basis)
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3,3'-Diethylthiacarbocyanine iodide [DiSC2(3)] ≥98.0% (by HPLC, total nitrogen)
Supplier: TCI
3,3'-Diethylthiacarbocyanine iodide [DiSC2(3)] ≥98.0% (by HPLC, total nitrogen)
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Anti-PS2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Supplier: Bioss
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
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Anti-MAP7D1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Supplier: Bioss
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.
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Anti-HES2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Supplier: Bioss
The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
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Anti-CALCR Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Supplier: Bioss
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
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Anti-ITGA5 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Supplier: Bioss
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.
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Anti-MBP Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Supplier: Bioss
Oligodendrocyte Marker The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
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Anti-ARC Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Supplier: Bioss
Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.
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Anti-CD74 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Supplier: Bioss
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
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6-Bromo-1,4-dihydro-2H-3,1-benzoxazin-2-one 95%
Supplier: Apollo Scientific
6-Bromo-1,4-dihydro-2H-3,1-benzoxazin-2-one 95%
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3,5-Diaminobenzoic acid dihydrochloride ≥98.0% (by HPLC, titration analysis)
Supplier: TCI
3,5-Diaminobenzoic acid dihydrochloride ≥98.0% (by HPLC, titration analysis)
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6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one 97%
Supplier: Apollo Scientific
6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one 97%
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Tris{tris[3,5-bis(trifluoromethyl)phenyl]phosphine}palladium
Supplier: Apollo Scientific
Tris{tris[3,5-bis(trifluoromethyl)phenyl]phosphine}palladium
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6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione 96%
Supplier: Apollo Scientific
6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione 96%
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3,5-Dimethyl-4-propoxyphenylboronic acid (contains varying amounts of Anhydride)
Supplier: TCI
3,5-Dimethyl-4-propoxyphenylboronic acid (contains varying amounts of Anhydride)
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[5,5'-Biisobenzofuran]-1,1',3,3'-tetraone ≥98.0% (by titrimetric analysis)
Supplier: TCI
[5,5'-Biisobenzofuran]-1,1',3,3'-tetraone ≥98.0% (by titrimetric analysis)
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3,7-Dibromo-10-hexylphenothiazine ≥98.0% (by HPLC, total nitrogen)
Supplier: TCI
3,7-Dibromo-10-hexylphenothiazine ≥98.0% (by HPLC, total nitrogen)
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trans-3,5-Difluorocinnamic acid ≥98.0% (by GC, titration analysis)
Supplier: TCI
trans-3,5-Difluorocinnamic acid ≥98.0% (by GC, titration analysis)
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Anti-ACTN Mouse Monoclonal Antibody [clone: SA-20]
Supplier: US Biological
Anti-ACTN Mouse Monoclonal Antibody [clone: SA-20]
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Anti-PLVAP Rat Monoclonal Antibody [clone: MECA-32]
Supplier: US Biological
Anti-PLVAP Rat Monoclonal Antibody [clone: MECA-32]
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Anti-TUBB3 Mouse Monoclonal Antibody [clone: TU-20]
Supplier: US Biological
Anti-TUBB3 Mouse Monoclonal Antibody [clone: TU-20]
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Anti-Solute Carrier Family 10 Rabbit Polyclonal Antibody
Supplier: US Biological
Anti-Solute Carrier Family 10 Rabbit Polyclonal Antibody
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Anti-AMIGO1 Mouse Monoclonal Antibody [clone: S86-36]
Supplier: US Biological
Anti-AMIGO1 Mouse Monoclonal Antibody [clone: S86-36]