62260 Results for: "Adipohydrazide&pageNo=50"

Supplier: DEUTSCH NEUMANN

HOLLOW STOPPERS NAT. RUBB. RED 19/17MM 1 * 100 items

Supplier: Epredia

Microslide Superfrost Print 90° yellow glass cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide superfrost 90° cc pink glass+box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide Superfrost 45° blue glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide Superfrost 45° yellow glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: JM BROSSERIE

BRUSH CLEAN Ø50MM L=200MM PA WH 0.6MM 1 * 10 items

Supplier: Epredia

Microslide Superfrost 90° CC yellow glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide Superfrost 90° CC blue glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: KGW

COLD TRAP TYP KF 54V-K16-Z-360 1 * 1 items

Supplier: Epredia

Microslide Superfrost 90° CC white glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: MACRON AVANTOR BRAND

L-Arginine hydrochloride 98.5-101.5% (dried basis) USP, FCC, Multi-Compendial, Macron Fine Chemicals™

Supplier: SAMCO

PIPETTE T/FER EXT/F/TIP STER PE 1.7ML 1 * 3.200 items

Supplier: Amarell

General purpose thermometer, enclosed scale, cap. lens front, red special liquid, -10+60:1C, total immersion, 200x7-8mm long, with ring at top 1 * 1 items

Supplier: Epredia

Microslide Superfrost 45° green glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide 45° frosted 20mm glass cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: ProSci Inc.

Human EN-RAGE belongs to the S100/calgranulin superfamily. There are at least 21 different S100 proteins and the protein is 100% soluble in ammonium sulfate at neutral pH. S100 proteins play a role in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response.Human EN-RAGE is characterized by two EF-hand calcium-binding motifs, zinc- and copper-binding protein.S100A12 is a disulfide-linked homodimer and the interface between the two subunits is composed mostly of hydrophobic residues.Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. EN-RAGE acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also acts as a monocyte and mast cell chemoattractant. Moreover, it can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. It can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+from their active sites.

Supplier: Thermo Orion

These bench top meters with conductivity module meet most challenging applications for pH, ion concentration, mV, ORP and temperature. The meters offer interchangeable measurement modules that allow multiple users to customise four separate channels to meet their specific requirements.

Supplier: Epredia

Microslide Superfrost 45° white glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: Epredia

Microslide Superfrost 90° CC green glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: MACRON AVANTOR BRAND

L-Arginine hydrochloride 98.5-101.0% USP, Multi-Compendial, meets analytical specification of ChP, BP, JP, Ph. Eur., Macron Fine Chemicals™

Supplier: VICI

C75TH-1673EUHB - 3 mpos trapping-path, u-electric, USB 1/16*.25mm, 50C/10000psi liq, N60C/E3 Electric Universal Actuator Serial interface: USB 1 * 1 items

Supplier: witeg Labortechnik

HOMOGENIZER HG-15D-SET 1 * 1 items

Supplier: Hospidex

Microsyringe 50µl GC standard with glass handle and fixed needle 1 * 1 items

Supplier: Hospidex

Microsyringe 50µl GC standard with glass handle and interchangeable needle 1 * 1 items

Supplier: ProSci Inc.

R-spondin-1 is also known as Roof plate-specific Spondin 1 (RSPO1) and cysteinerich and single thrombospondin domain containing protein 3 (Cristin 3), is a secreted protein which belongs to the R-Spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. All Rspondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. Like other R-Spondins, R-Spondin-1 contains two adjacent cysteinerich furinlike domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Only the furinlike domains are needed for β-catenin stabilisation. A putative nuclear localisation signal at the C-terminus may allow some expression in the nucleus. Potential isoforms of 200 and 236 aa have an alternate, shorter N-terminus or are missing aa 146-208, respectively. R-Spondin-1 is expressed in early development at the roof plate boundary and is thought to contribute to dorsal neural tube development. Human RSPO1 disruption results in a recessive syndrome characterized by XX sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. It has been shown that the complete female-to-male sex reversal is due to the absence of the testis-determining gene, SRY. R-Spondin-1 regulates Wnt/β-catenin by competing with the Wnt antagonist DKK1 for binding to the Wnt co receptors, Kremen and LRP6, reducing their DKK1 mediated internalisation. Reports differ on whether R-spondin 1 binds LRP6 directly.

Supplier: ProSci Inc.

tumour Necrosis Factor- alpha (TNF- alpha) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF- alpha while cells that express CD8 secrete little or no TNF- alpha. Synthesis of TNF- alpha can be induced by many different stimuli including interferons, IL2, and GM-CSF. The clinical use of the potent anti-tumour activity of TNF- alpha has been limited by the proinflammatory side effects such as fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF- alpha mutants with low systemic toxicity has been of intense pharmacological interest. Human TNF- alpha that binds to murine TNF-R55 but not murine TNF-R7, exhibits retained anti-tumour activity and reduced systemic toxicity in mice compared with murine TNF- alpha, which binds to both murine TNF receptors. Based on these results, many TNF- alpha mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumour cell lines in vitro and have exhibited lower systemic toxicity in vivo. Recombinant Human TNF- alpha High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8, Lys9, Arg10 and Phe157. This mutant form has been shown to have increased activity with less inflammatory side effects in vivo.

Supplier: ProSci Inc.

The Fas is also known as FAS receptor (FasR), apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6). is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two apoptosis pathways, the other being the mitochondrial pathway. FasR is located on chromosome 10 in humans and 19 in mice. Similar sequences related by evolution (orthologs) are found in most mammals. Fas forms the death-inducing signaling complex (DISC) upon ligand binding. Membrane-anchored Fas ligand trimer on the surface of an adjacent cell causes trimerization of Fas receptor. This event is also mimicked by binding of an agonistic Fas antibody, though some evidence suggests that the apoptotic signal induced by the antibody is unreliable in the study of Fas signaling. To this end, several clever ways of trimerizing the antibody for in vitro research have been employed.Upon ensuing death domain (DD) aggregation, the receptor complex is internalized via the cellular endosomal machinery. This allows the adaptor molecule FADD to bind the death domain of Fas through its own death domain. Recently, Fas has also been shown to promote tumor growth, since during tumor progression, it is frequently downregulated or cells are rendered apoptosis resistant. Cancer cells in general, regardless of their Fas apoptosis sensitivity, depend on constitutive activity of Fas. This is stimulated by cancer-produced Fas ligand for optimal growth.

Supplier: ProSci Inc.

tumour Necrosis Factor- alpha (TNF- alpha) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF- alpha while cells that express CD8 secrete little or no TNF- alpha. Synthesis of TNF- alpha can be induced by many different stimuli including interferons, IL2, and GM-CSF. The clinical use of the potent anti-tumour activity of TNF- alpha has been limited by the proinflammatory side effects such as fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF- alpha mutants with low systemic toxicity has been of intense pharmacological interest. Human TNF- alpha that binds to murine TNF-R55 but not murine TNF-R7, exhibits retained anti-tumour activity and reduced systemic toxicity in mice compared with murine TNF- alpha, which binds to both murine TNF receptors. Based on these results, many TNF- alpha mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumour cell lines in vitro and have exhibited lower systemic toxicity in vivo. Recombinant Human TNF- alpha High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8, Lys9, Arg10 and Phe157. This mutant form has been shown to have increased activity with less inflammatory side effects in vivo.

Supplier: HAMILTON ROBOTICS

50ul core tips clear stack, 5x4 stacks / 11520 1 * 11.520 items

Supplier: Amarell

Thermometer similar to IP 76 C, solid stem, white backed, 10+55:0,5°C, capillary tube specially coated inside, with non-wetting blu e special liquid, durable pigment, null