92246 Results for: "3,5-Dichlorosalicylic+acid"

Supplier: ProSci Inc.

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES3 is thought act as a tumor suppressor or growth regulator.Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator.

Supplier: GERING

Saccharimeter 0-30 0,1 BALL WRK. CRT. 1 * 1 items

Supplier: U-Power

JACKET TURBO GREY METEORITE S 1 * 1 items

Supplier: witeg Labortechnik

FLASK, ROUND BOTTOM, CENTER NECK, ACC TO DIN 12348, 500 ML, ST 34 1 * 1 items

Supplier: AGILENT

Economic, entry-level system for the analysis of up to 16 DNA and RNA samples per run.

Supplier: witeg Labortechnik

Tubing threaded 90x130x3.5mm gl80 ,with restriction,acc. to din 12216, with iso screw thread,made of borosilicate glass 1 * 1 items

Supplier: NEW PIG

PIG® SUPER Absorbent Sock is great for high-volume machine leaks. Soaks up nearly twice as much liquid as other maintenance socks.

Supplier: ProSci Inc.

SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.

Supplier: Merck

All Spectroquant® test kits can be used with the Prove range of spectrophotometers and Nova 60/60A instruments. Tests can be used not only on photometers and spectrophotometer from Merck, but also on photometers and spectrophotometers from other suppliers (programming details available on request). Spectroquant® cell test kits.

Supplier: NEW PIG

This "Grab & go" spill response kit has a see-through design for easy inventory of spill response supplies.

Supplier: U-Power

TROUSERS RACE GREY METEORITE SIZE 44 1 * 1 items

Supplier: SCHURR SCHUHVERTRIEB

SANDAL ZWICKAU 11622 WHITE SIZE 48 1 * 1 PAIR

Supplier: SCHURR SCHUHVERTRIEB

SANDAL ZWICKAU 11622 WHITE SIZE 46 1 * 1 PAIR

Supplier: Bioss

Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.

Supplier: DWK Life Sciences

TUBE THREADED SODA LIME GLASS JOINT 1 * 100 items

Supplier: SciLabware

Spherical Joint Rotulex Male 3 (BIBBY RM35) 1 * 30 items

Supplier: THERMO HYBAID

External Remote Keypad including Cuvette Chamber for CelljecT Duo 1 * 1 items

Supplier: U-Power

TROUSERS RACE BLACK CARBON S.44 1 * 1 items

Supplier: Retsch GmbH

Ring sieve ZM 300 stainless steel, with reinforced rim trapezoid holes 0.35 mm 1 * 1 items

Supplier: HAAKE

ROTOR C35 0.5°/TI FOR MARS IQ 1 * 1 items

Supplier: SCHURR SCHUHVERTRIEB

SANDAL ZWICKAU 11622 WHITE SIZE 44 1 * 1 PAIR

Supplier: SCHURR SCHUHVERTRIEB

SANDAL ZWICKAU 11622 WHITE SIZE 47 1 * 1 PAIR

Supplier: witeg Labortechnik

Tubing threaded 85x130x3.5mm gl90 with screw threaded, straight,acc. to din 12216, with iso screw thread,made of borosilicate glass , available with screw thread gl, rd or svl null

Supplier: witeg Labortechnik

Tubing threaded 56x130x3.5mm gl60 with screw threaded, straight,acc. to din 12216, with iso screw thread,made of borosilicate glass , available with screw thread gl, rd or svl null

Supplier: SCHURR SCHUHVERTRIEB

Sandal Zwickau 11622 white, Gr. 42 1 * 1 PAIR

Supplier: SCHURR SCHUHVERTRIEB

SANDAL ZWICKAU 11622 WHITE SIZE 43 1 * 1 PAIR

Supplier: Abcam

Sensitive, reproducible assay for initial screening of potential glutaminase inhibitors.

Supplier: Bioss

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Supplier: Bioss

Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.

Supplier: Thermo Fisher Scientific

Rigid PC frame, thin-walled PP wells. Ultra-rigid 96-well PCR plates with rounded V-bottom wells designed for robotic applications.