- Antibody type:Primary
- Antigen name:Tripartite motif-containing protein 72
- Antigen symbol:TRIM72
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- ImmunoChemistry:Yes
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Epitope:Amino Acid Range = 299-327
- Form:Liquid
- Gene ID:Q6ZMU5
- Antigen synonyms:TRIM72
- Modification:None
- Storage buffer:Supplied in PBS with 0,09% (W/V) sodium azide
- Molecular weight:53 kDa
- Storage temperature:Store at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:0,42 mg/ml
- Shipping temperature:4 °C
- Immunogen:This TRIM72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the C-terminal region of human TRIM72.
- Purification:This antibody is purified through a protein A column, followed by peptide affinity purification.
- Size:400 µl
- Pk:400 µl
TRIM72 is a muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
For WB starting dilution is: 1:2000. For IHC-P starting dilution is: 1:10~50.
Type: Primary
Antigen: TRIM72
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: Rabbit Ig
Reactivity: Human, Mouse, Rat