- Antibody type:Primary
- Antigen name:GPCR6A/GPCR33
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Rat
- Western blot:Yes
- Epitope:131-230/926
- Form:Liquid
- Gene ID:222545
- Antigen synonyms:gprc6a|GPCR 6A|OTTHUMP00000017075|hGPCR33|GPR C6A|G protein coupled receptor 33|G-protein coupled receptor GPCR33|hGPCR 33|GPCR|GPC6A_HUMAN|hGPRC6A|G-protein coupled receptor family C group 6 member A|GPRC 6A|GPCR 33|bA86F4.3|GPCR33|G protein coupled receptor family C group 6 member A
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:103 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human GPCR6A/GPCR33
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
GPRC6A (G protein-coupled receptor family C group 6 member A) is a 928 amino acid protein encoded by the mouse Gprc6a gene. GPRC6A is a member of the G protein-coupled receptor 3 family. This receptor is activated by both amino acids and extracellular concentration of calcium ions. The activity of GPRC6A is mediated by a G protein that activates a phosphatidylinositol-calcium second messenger system. GPRC6A senses changes in the extracellular concentration of calcium ions, suggesting that it may mediate extracellular calcium-sensing responses in osteoblasts. Osteocalin stimulates the activity of GPRC6A in the presence of calcium. GPRC6A also acts as a receptor for amino acids, with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine. Its affinity for amino acids suggests that it may act as a regulatory component of the urea cycle. GPRC6A is expressed at high levels in liver, lung, spleen and heart, and at lower levels in kidney, skeletal muscle and brain.
Type: Primary
Antigen: GPCR6A/GPCR33
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 131-230/926
Host: Rabbit
Isotype: IgG
Reactivity: Rat