Specifications
- Antibody type:Primary
- Antigen name:SOSSC
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Epitope:11-80/104
- Form:Liquid
- Gene ID:58493
- Antigen synonyms:SOSSC_HUMAN|Chromosome 9 open reading frame 80|Sensor of ssDNA subunit C|Ssbip1|hSSBIP1|SSB-interacting protein 1|INIP|SOSS complex subunit C|INTS3- and NABP-interacting protein|C9orf80|SOSS C|MISE|SOSSC|Single-stranded DNA-binding protein-interacting protein 1|RP11-276E15.2|Sensor of single-strand DNA complex subunit C|SOSS-C
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human SOSSC/C9orf80
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
The SOSS (Sensor of single-strand DNA) complex consists of multiple proteins that promote DNA repair and G2/M checkpoint downstream of the MRN (Mre11, Rad50 and Nbs1) complex. The complex is composed of SSBP1, INTS3 and C9orf80. Specifically, the SOSS complex binds to ssDNA at DNA lesions that influences diverse endpoints in the cellular DNA damage response. The complex is required for efficient homologous recombination-dependent repair of double-stranded breaks and ATM-dependent Signalling pathways. C9orf80, also known as SOSS complex subunit C and Single-stranded DNA-binding protein-interacting protein 1 (SSBIP1), is a 104 amino acid nuclear protein that is a component of the SOSS complex. Upon DNA damage, C9orf80 along with other components of the SOSS complex migrate to the nucleus. There are two isoforms of C9orf80 that are produced as a result of alternative splicing events.
Type: Primary
Antigen: SOSSC
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 11-80/104
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat