Specifications
- Antibody type:Primary
- Antigen name:DTNBP1
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 488
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Rat
- Epitope:101-200/351
- Form:Liquid
- Gene ID:84062
- Antigen synonyms:DBND|Biogenesis of lysosome-related organelles complex 1 subunit 8|BLOC-1 subunit 8|Dysbindin|HPS7|BLOC1S8|HPS7 protein|Dysbindin-1|SDY|My031|DTNBP1|Dystrobrevin-binding protein 1|Hermansky-Pudlak syndrome 7 protein
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:39 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human DTNBP1
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.
Type: Primary
Antigen: DTNBP1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 488
Public Immunogen Range: 101-200/351
Host: Rabbit
Isotype: IgG
Reactivity: Rat