Specifications
- Antibody type:Primary
- Antigen name:c-Raf Thr269
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Mouse
- Form:Liquid
- Gene ID:5894
- Antigen synonyms:v-raf-1 murine leukemia viral oncogene homolog 1|Raf-1|Raf 1|RAF1|Craf1|BB129353|Craf 1 transforming gene|RAF|cRaf|Murine sarcoma 3611 oncogene 1|AA990557|v-Raf|EC 2.7.11.1|Craf1 transforming gene|proto-oncogene c-RAF|6430402F14Rik|vraf1 murine leukemia viral oncogene homolog 1|RAF1phospho T269|murine leukemia viral v-raf-1 oncogene homolog 1 3611-MSV|C-RAF|c-Raf|MGC102375|Raf proto oncogene serine/threonine protein kinase|D830050J10Rik|c Raf
- Modification:Phosphorylation (Thr269)
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:73 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic phosphopeptide derived from human c-Raf around the phosphorylation site of Thr269
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
The Raf family of serine/threonine specific kinases is comprised of three members (aRaf, bRaf, and cRaf) that play a critical role in regulating cell growth and differentiation, and couple growth factor receptor stimulation to nuclear transcription factors via the Ras/mitogen activated protein kinase (MAPK) pathway. cRaf kinase (also known as Raf1) is a small GTPase like kinase of 73 kDa, and is a signal transducer of multiple extracellular stimuli that is regulated by several pathways, and that once activated, phosphorylates MEK which in turn phosphorylates ERK. Raf1 is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is part of the Ras dependent signaling pathway from receptors to the nucleus.
Type: Primary
Antigen: c-Raf Thr269
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse