Specifications
- Antibody type:Primary
- Antigen name:TEM8
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Mouse
- Western blot:Yes
- Epitope:201-300/564
- Form:Liquid
- Gene ID:84168
- Antigen synonyms:Anthrax toxin receptor 1 precursor|Anthrax toxin receptor-1|ATR|ANTR1_HUMAN|TEM-8|Anthrax toxin receptor 1|TEM8|FLJ21776|FLJ11298|ANTXR1|Tumor endothelial marker 8 precursor|Tumor Endothelial Marker 8|TEM 8|ANTXR 1
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:63 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human TEM8
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colourectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edoema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
Type: Primary
Antigen: TEM8
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 201-300/564
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse