- Antibody type:Primary
- Antigen name:Lymphocyte-activation gene 3
- Antigen symbol:LAG3
- Clonality:Monoclonal
- Conjugation:Biotin
- ELISA:Yes
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Western blot:Yes
- Seq:01
- Form:Liquid. In PBS containing 0,02% sodium azide
- Concentration:1 mg/ml
- Purification:Purified from concentrated hybridoma tissue culture supernatant by Protein A Sepharose™ CL-4B Flow Fast Column
- Size:100 µg
- Pk:100 µG
The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa). The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses.
- For ELISA, Flow Cytometry
Recognizes the 30 aa extra-loop of the first N-terminal D1 domain of human LAG-3.
Type: Primary
Antigen: LAG3
Clonality: Monoclonal
Clone:
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human