Specifications
- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Tag sequence:C-6 His, N-T7 tag
- Storage conditions:Store at −20 °C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Protein synonyms:SLP-76 tyrosine phosphoprotein|SH2 domain-containing leukocyte protein of 76 kDa|LCP2|Lymphocyte cytosolic protein 2|SLP76
- Protein/peptide name:SLP-76
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:62.6 kD
- Sequence:Met1-Pro533
- Formulation:Supplied as a 0.2 um filtered solution of 20mM Tris,150mM NaCl,20% glycerol，pH 8.5. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Tested applications:Bioassay
Specifications
About this item
Lymphocyte cytosolic protein 2（LCP2）contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cell lines. LCP2 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. It is phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2 during post-translational modification. Studies using LCP2-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
Fusion-Tag: C-6 His, N-T7 tag
This recombinant protein can be used for biological assays. For research use only.