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Human recombinant GDF11 (from cells)
Catalog # PRSI91-641
Supplier:  ProSci Inc.
CAS Number:  
Human recombinant GDF11 (from cells)
Catalog # PRSI91-641
Supplier:  ProSci Inc.
CAS Number:  

Specifications

  • Pk:
    50 µG
  • Protein/peptide type:
    Recombinant
  • Source:
    Cells
  • Species:
    Human
  • Storage conditions:
    Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
  • Protein synonyms:
    BMP-11|Growth/differentiation factor 11|Bone morphogenetic protein 11|GDF-11
  • Protein/peptide name:
    GDF11
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Molecular weight:
    12.6 kD
  • Sequence:
    Asn299-Ser407
  • Formulation:
    Lyophilized from a 0.2 um filtered solution of PBS,pH7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested applications:
    Bioassay

Specifications

About this item

Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development.

  • This recombinant protein can be used for biological assays. For research use only.