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Human recombinant podoplanin (from cells)
  PRSI91-478
 :  ProSci Inc.
 :  
Human recombinant podoplanin (from cells)
  PRSI91-478
 :  ProSci Inc.
 :  

 

  • Pk:
    50 µG
  • Protein/peptide type:
    Recombinant
  • Source:
    Cells
  • Species:
    Human
  • Tag sequence:
    C-6 His tag
  • Storage conditions:
    Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
  • Protein synonyms:
    PDPN|T1A|Glycoprotein 36|PA2.26 Antigen|T1-Alpha|Aggrus|Gp36|Podoplanin
  • Protein/peptide name:
    Podoplanin
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Molecular weight:
    12.16 kD
  • Sequence:
    Ala23-Thr131
  • Formulation:
    Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested applications:
    Bioassay

 

 

Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, and major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless, it doesn’t have any effect on amino acid transport and the aquaporin-type water channels.

  • This recombinant protein can be used for biological assays. For research use only.

Fusion-Tag: C-6 His tag