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Human recombinant PHS (from E. coli)
Human recombinant PHS (from E. coli)
Catalog # PRSI91-226
Supplier:  ProSci Inc.
CAS Number:  
Human recombinant PHS (from E. coli)
Catalog # PRSI91-226
Supplier:  ProSci Inc.
CAS Number:  

Specifications

  • Pk:
    50 µG
  • Protein/peptide type:
    Recombinant
  • Source:
    E. coli
  • Species:
    Human
  • Environmentally Preferable:
  • Tag sequence:
    N-6 His tag
  • Storage conditions:
    Store at −20 °C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
  • Protein synonyms:
    Dimerization Cofactor of HNF1|Pterin-4-Alpha-Carbinolamine Dehydratase|Phenylalanine Hydroxylase-Stimulating Protein|PCBD|PCBD1|Pterin Carbinolamine Dehydratase|Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha|PCD|PHS|4-Alpha-Hydroxy-Tetrahydropterin Dehydratase|DCoH
  • Protein/peptide name:
    PHS
  • Purity:
    > 95% as determined by reducing SDS-PAGE
  • Molecular weight:
    14.2 kD
  • Sequence:
    Ala2-Thr104
  • Formulation:
    Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, 1mM DTT, pH 8.0. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested applications:
    Bioassay

Specifications

About this item

Pterin-4- alpha-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4- alpha-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.

  • This recombinant protein can be used for biological assays. For research use only.

Fusion-Tag: N-6 His tag