Specifiche
- Tipo anticorpo:Primary
- Tipo di anticorpi:Calcium Binding Protein 39
- Simbolo dell'antigene:CAB39
- Clonalità:Policlonale
- Coniugazione:FITC (Fluoresceina Isotiocionato)
- Ospite:Rabbit
- ImmunoChimica:Yes
- Isotipo:IgG
- Reattività:Human,Rat,Mouse
- Assorbimento incrociato:No
- Forma:liquid
- ID gene:51719
- Sinomini antigene:MO25|CGI-66
- Tampone di conservazione:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Temperatura di conservazione:Store at 4°C for 12 months
- Concentrazione:1 μg/μl
- Temperatura di spedizione:4°C
- Purificazione:Purified by Protein A
- Conf:100 µl
Specifiche
Informazioni su questo articolo
Mouse protein 25 alpha (MO25 alpha, CAB39) is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). CAB39 binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity. Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-MO25 during skeletal muscle contraction may be regulated by allosteric mechanisms.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: CAB39
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse, Rat