Anti-H3-K4-HMTase SETD7 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

BOSSBS-6191R-A680

Anti-H3-K4-HMTase SETD7 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

BOSSBS-6191R-A680

Antibody type:
Primary
Antigen name:
H3-K4-HMTase SETD7
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 680
Flow cytometry:
Yes
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Human
Western blot:
Yes
Epitope:
271-366/366
Form:
Liquid
Gene ID:
80854
Antigen synonyms:
Histone-lysine N-methyltransferase SETD7|KIAA1717|Histone lysine N methyltransferase|Lysine methyltransferase|KMT7|SET 9|Histone H3 K4 methyltransferase|SET domain containing lysine methyltransferase 7|SET7/9|H4 lysine 4 specic|OTTHUMP00000220049|Lysine N-methyltransferase 7|H3-K4-HMTase SETD7|SET domain containing protein 7|SET 7/9|H3 K4 HMTase|SET domain-containing protein 7|SET9|OTTHUMP00000164543|Histone lysine N methyltransferase H3 lysine 4 specic SET7|SET7|SET domain containing protein 8|Setd7|SET 7|FLJ21193|SETD7_HUMAN|Histone H4 K4 methyltransferase|Histone H3 lysine 4 specic methyltransferase|Histone H3-K4 methyltransferase SETD7|SET D7
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Molecular weight:
41 kDa
Storage temperature:
Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human Histone H4 K4 methyltransferase SETD7
Tested applications:
ICC
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognising and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilising p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.

Type: Primary
Antigen: H3-K4-HMTase SETD7
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 271-366/366
Host: Rabbit
Isotype: IgG
Reactivity: Human