375 Results for: "merck1"

Supplier: Abcam

Rabbit monoclonal [EPR16667] to MEK1 - BSA and Azide free (Capture).

Supplier: Abcam

APC Rabbit monoclonal [EPR16667] to MEK1 + MEK2.

Supplier: ANTIBODIES.COM

Rabbit monoclonal [ARC0292] antibody to MEK1 + MEK2 for WB with samples derived from Human, Mouse and Rat.

Supplier: Bioss

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyse the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Supplier: Bioss

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyse the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Supplier: Abcam

Rabbit monoclonal [E342] to MEK1 - BSA and Azide free (Detector).

Supplier: Abcam

PE Rabbit monoclonal [EPR16667] to MEK1 + MEK2.

Supplier: Abcam

Rabbit recombinant multiclonal [8HCLC] to MEK1 (phospho T386).

Supplier: Bioss

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyse the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Supplier: Abcam

Alexa Fluor® 488 Rabbit monoclonal [EPR16667] to MEK1 + MEK2.

Supplier: Boster Bio

Rabbit IgG polyclonal antibody for Dual specificity mitogen-activated protein kinase kinase 1(MAP2K1) detection. Tested with WB, IHC-P, ICC in Human; Mouse; Rat.

Supplier: Abcam

Rabbit monoclonal [EPR16667] to MEK1 + MEK2 - BSA and Azide free.

Supplier: Abcam

Alexa Fluor® 594 Rabbit monoclonal [EPR16667] to MEK1 + MEK2.

Supplier: Abcam

Alexa Fluor® 647 Rabbit monoclonal [E342] to MEK1.

Supplier: Abcam

HRP Rabbit monoclonal [EPR16667] to MEK1 + MEK2.

Supplier: Abcam

Alexa Fluor® 568 Rabbit monoclonal [E342] to MEK1.

Supplier: Abcam

Alexa Fluor® 555 Rabbit monoclonal [EPR16667] to MEK1 + MEK2.

Supplier: Abcam

HRP Rabbit monoclonal [EPR3338] to MEK1 (phospho S298).

Supplier: ANTIBODIES.COM

Rabbit monoclonal [ARC1565] antibody to MEK1 (phospho Ser298) for WB with samples derived from human and rat.

Supplier: ANTIBODIES.COM

Rabbit polyclonal antibody to MEK1 + MEK2 (phospho Ser217) for WB, IHC and ELISA with samples derived from Human, Mouse and Rat.

Supplier: Abcam

APC Rabbit monoclonal [EPR3338] to MEK1 (phospho S298).

Supplier: Abcam

Human/Mouse/Rat MEK1 Antibody Pair - BSA and Azide free

Supplier: ANTIBODIES.COM

Rabbit polyclonal antibody to MEK1 + MEK2 (phospho Ser221) for WB, IHC and ELISA with samples derived from Human, Mouse and Rat.

Supplier: Bioss

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Supplier: Bioss

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Supplier: ANTIBODIES.COM

Rabbit monoclonal [ARC1566] antibody to MEK1 (phospho Thr292) for WB with samples derived from human, mouse and rat.

Supplier: Bioss

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Supplier: Abcam

Rabbit monoclonal [EPR3338] to MEK1 (phospho S298) - BSA and Azide free.

Supplier: Abcam

Rabbit monoclonal [MEK1S298-H8] to MEK1 (phospho S298).

Supplier: Bioss

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.