2421 Results for: "STEMCELL Technologies"

Supplier: STEMCELL Technologies

Mouse monoclonal IgG2a, kappa isotype control antibody, FITC-conjugated.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2a, kappa isotype control antibody, unconjugated.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2b antibody against mouse CD24, unconjugated.

Supplier: STEMCELL Technologies

Immunomagnetic negative selection of human pan-B cells

Supplier: STEMCELL Technologies

Interleukin 1 beta (IL-1β) is synthesised as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. Mice deficient in IL-1β do not show phenotypical differences from wild-type mice; however, they have a reduced response to inflammation, suggesting that IL-1β plays a key role in inflammatory diseases (Dinarello).

Supplier: STEMCELL Technologies

Interleukin 11 (IL-11) is a pleiotropic cytokine with effects on various tissues including the bone marrow, brain, and intestinal mucosa (Du andamp; Williams). It belongs to the IL-6 family of cytokines that share a common signal transducer, gp130. IL-11 induces the proliferation of hematopoietic stem cells (Lemoli et al.) and megakaryocytic progenitor cells (Bruno et al.), the maturation of megakaryocytes (Burstein et al.), and the production of platelets (Neben et al.). IL-11 is produced by a variety of cell types including hematopoietic cells, mesenchymal cells, epithelial cells, and neuronal cells. It was first cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102 (Kawashima et al.). The binding of IL-11 to its receptor induces heterodimerization with the gp130 subunit and activation of JAK tyrosine kinases. IL-11 was the first pharmacologic agent approved for the treatment of chemotherapy-induced thrombocytopenia. IL-11 also plays a role in cancer progression by inducing the proliferation of epithelial cancer cells and the survival of metastatic cells at distant organs. Recently, IL-11 has gained interest for its role in the pathogenesis of diseases in dysregulated mucosal homeostasis associated with STAT3 upregulation, including gastrointestinal cancers (Putoczki et al.).

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human B cells.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched human CD8+ T cells.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD8a, APC-conjugated.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched mouse mesenchymal stem/progenitor cells

Supplier: STEMCELL Technologies

Immunomagnetic isolation of B-CLL cells directly from whole blood

Supplier: STEMCELL Technologies

Complete kit for CD34+ cells from cord blood.

Supplier: STEMCELL Technologies

Medium without cytokines.

Supplier: STEMCELL Technologies

Base methylcellulose medium for in vitro differentiation of mouse ES or iPS cells to hematopoietic or endothelial progenitor cells.

Supplier: STEMCELL Technologies

Purified human vitronectin solution for tissue engineering research and cell culture - 0,2 ml.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2b antibody against mouse CD117 (c-Kit), unconjugated.

Supplier: STEMCELL Technologies

Rat monoclonal IgG2b antibody against mouse TER119, unconjugated.

Supplier: STEMCELL Technologies

Neurotrophin-4 (NT-4) is a member of the nerve growth factor family which includes neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF), all of which promote the differentiation, growth, and survival of peripheral and central nervous system neurons (Eide et al.). NT-4 binds and activates tropomyosin receptor kinase B (TrkB) at the cell surface; in doing so, it acts as a survival factor for certain populations of sensory neurons (Berkemeier et al.; Skaper). It has been shown that NT-4, together with BDNF, promotes neurite extension and maturation, as well as maintenance of differentiated cerebellar granule cells (Gao et al.).

Supplier: STEMCELL Technologies

RANTES (regulated upon activation, normal T cell expressed and secreted), also known as CCL5, is a member of the CC family of chemokines and is able to recruit leukocytes to sites of inflammation (Schall et al.). RANTES is secreted by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells (Aldinucci and Colombatti; Soria and Ben-Baruch). This chemokine exerts its effect by interacting with the chemokine receptors CCR1, CCR3, CCR4, and CCR5. RANTES plays an active role in recruiting a variety of leukocytes into inflammatory sites, including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and IFN-γ, RANTES also induces the activation and proliferation of NK cells to generate CC chemokine-activated killer cells, which are highly cytolytic (Lv et al.; Maghazachi et al.). It has been shown that RANTES produced by CD8+ T cells inhibits HIV infection of primary human peripheral blood mononuclear cells (Appay and Rowland-Jones; Cocchi et al.).

Supplier: STEMCELL Technologies

Nerve growth factor (NGF)-beta is a prototypical member of the neurotrophin family and has a role in the survival and growth of neural cells, regulating cell growth, promoting differentiation into neurons, and neuron migration. The beta subtype of NGF is biologically active in comparison to the alpha-2 and gamma-2 subtypes. NGF-beta in its secreted form can bind to tyrosine kinase A (TrkA) receptor with high affinity and to p75 (NTR) with low affinity (Levi and Alemà; Sofroniew et al.). NGF has been shown to possess pro-inflammatory and pro-fibrogenic properties (Micera et al.). It has also been shown that overexpression of NGF-beta promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathways (Yuan et al.).

Supplier: STEMCELL Technologies

Rat monoclonal IgG2a antibody against mouse CD19, FITC-conjugated.

Supplier: STEMCELL Technologies

Immunomagnetic positive selection of particle-free human cells labelled with PE-conjugated antibodies.

Supplier: STEMCELL Technologies

Immunomagnetic isolation of untouched rat CD8+ T cells

Supplier: STEMCELL Technologies

Immunodensity isolation of untouched T cells for HLA analysis.

Supplier: STEMCELL Technologies

Serum-free culture supplement for expansion of human CD34+ hematopoietic cells.

Supplier: STEMCELL Technologies

Cell culture supplement. 1×3 ml vial.

Supplier: STEMCELL Technologies

Purified tropoelastin, human, lyophilised, for tissue engineering research and cell culture - 1 mg

Supplier: STEMCELL Technologies

Mouse monoclonal IgG2b antibody against human, rhesus, cynomolgus CD14, FITC-conjugated.

Supplier: STEMCELL Technologies

Serum-free medium and supplement for the measurement of drug toxicity on erythroid cells.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human SSEA-5, FITC-conjugated.