17456 Results for: "ENZO LIFE SCIENCES"

Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. Human caspase-4, thought to be the homolog of mouse caspase-11, may be an effective therapeutic target for treatment of septic shock.

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Anti-CCL22 Rat Monoclonal Antibody

Supplier: Enzo Life Sciences

Host: Rat, Isotype: IgG

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Anti-HIF1A Mouse Monoclonal Antibody

Supplier: Enzo Life Sciences

Oxygen availability plays a major role in the regulation of expression of many different genes including erythropoietin, nitric oxide synthase (NOS), heme oxygenase 1 (HO-1), glucose transporters and vascular growth factors necessary for the maintenance of homeostasis in hypoxic conditions. Hypoxia-inducible factor 1α (HIF-1α) has been identified as a bHLH-PAS family member which is instrumental in the oxygen-dependent regulation of these genes. HIF-1α rapidly accumulates in the nucleus upon exposure to hypoxic conditions where it heterodimerizes with the aryl hydrocarbon nuclear receptor translocator, ARNT, also referred to as HIF-1β.

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L(-)-Glutathione (reduced form)

Supplier: Enzo Life Sciences

L(-)-Glutathione (reduced form)

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ETA receptor antagonist [BQ-610]

Supplier: Enzo Life Sciences

30-fold more potent ETA antagonist than BQ-123 in pig aortic smooth muscle membrane assay, same activity as BQ-123 when tested on pig cerebellum membrane.

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Pam3Cys-Ser-(Lys)4 . trihydrochloride

Supplier: Enzo Life Sciences

Selective agonist of TLR1/TLR2 complex

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Ras inhibitory peptide

Supplier: Enzo Life Sciences

The peptide sequence corresponds to amino acid residues 1149-1158 of the guanine nucleotide-releasing factor hSos1, which is essential for the control of Ras activity. Blocks the binding of hSos1 to human Grb2, a protein that binds to activated receptor tyrosine kinases.

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Bovine;Human;Mouse;Rat Orexin A

Supplier: Enzo Life Sciences

Food intake modulator

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D-myo-Inositol-1,4,5-trisphosphate triammonium salt ≥98% (by HPLC)

Supplier: Enzo Life Sciences

D-myo-Inositol-1,4,5-trisphosphate triammonium salt ≥98% (by HPLC)

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Pilocarpine hydrochloride

Supplier: Enzo Life Sciences

Pilocarpine hydrochloride

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Anti-ESR2 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Host: Rabbit

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Anti-LEPR Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Host: Rabbit

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Anti-beta-COP Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Host: Rabbit

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Anti-FAS Mouse Monoclonal Antibody

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG3

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Methotrexate

Supplier: Enzo Life Sciences

Methotrexate

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Monensin monosodium salt

Supplier: Enzo Life Sciences

Monensin monosodium salt

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KillerTRAIL™ storage and dilution buffer

Supplier: Enzo Life Sciences

Storage and dilution buffer for use with the following products:
KillerTRAIL™, Soluble (human) (recombinant) (Prod. No. ALX-201-073)
SuperKillerTRAIL™, Soluble (human) (recombinant) (Prod. No. ALX-201-115)
SuperKillerTRAIL™, Soluble (mouse) (recombinant) (Prod. No. ALX-201-130)
Useful for prediluting the above mentioned products before preparing aliquots or performing experiments. Predilution with KillerTRAIL™ Storage and Dilution Buffer allows for easier handling of small working concentrations (sometimes only 0.1µl of the KillerTRAIL™ or SuperKillerTRAIL™ stock solution is necessary because of their high activity). Predilution with KillerTRAIL™ Storage and Dilution Buffer instead of medium or PBS prevents loss of biological activity. Can also be used as negative control.

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Anti-CNR1 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Host: Rabbit

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(-)-Eburnamonine ≥99%

Supplier: Enzo Life Sciences

Antihypoxic. Vasodilator.

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[-]-Deguelin ≥95% (by HPLC)

Supplier: Enzo Life Sciences

COX-2 inhibitor

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Pseudolaric acid B ≥95%

Supplier: Enzo Life Sciences

Activates PPAR alpha and the phospholipase C (PLC) signalling pathway. Stimulates peroxisomal fatty acyl-CoA oxidase activity. These effects can be blocked by staurosporine (Prod. No. ALX-380-014). Exhibits significant cytotoxic activities against numerous tumor cell lines. Binds tubulin. Inhibits angiogenesis. Reduces HIF-1alpha protein levels. Induces apoptosis. Antifungal.