Hamster (Armenian) monoclonal antibody against mouse CD69, PE-Cy7-conjugated.

• B cells
• Macrophages
• Monocytes
• Nk cells
• T cells

This monoclonal antibody (clone H1.2F3) reacts with mouse cluster of differentiation 69 (CD69), a type II transmembrane glycoprotein. CD69 is a 60 kDa disulfide bonded homodimer expressed on activated T cells, B cells, NK cells, neutrophils, and monocytes, where induction of CD69 rapidly occurs upon activation. CD69 is constitutively expressed on platelets and a subset of thymocytes. It functions as a co-stimulatory molecule that plays a role in activating and promoting the proliferation of T cells. Additionally, it can serve as an indicator for thymocytes engaged in T cell receptor (TCR)-mediated positive selection. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. It has also been documented that co-stimulation with the H1.2F3 antibody clone enhances the activation of T cells and macrophages. CD69 dysfunction is associated with diseases such as coccidioidomycosis and asthma. Use this recombinant monoclonal antibody in applications requiring detection of CD69, such as flow cytometry (FC).

Type:
Antigen: CD69
Clonality: Monoclonal
Clone: H1.2F3
Conjugation: PE-Cy7
Epitope:
Host: Hamster
Isotype: IgG
Reactivity: Mouse