Anti-CD137 (ILA) Mouse Monoclonal Antibody [clone: 4B4-1] (PE)

Catalog # STMC100-1356

Supplier: STEMCELL Technologies

Catalog # STMC100-1356

Supplier: STEMCELL Technologies

Specifications

Antigen name:
CD137 (ILA)
Clonality:
Monoclonal
Clone:
4B4-1
Conjugation:
PE (Phycoerythrin)
Host:
Mouse
Isotype:
IgG1 kappa
Reactivity:
Monkey,
Human
Gene ID:
3604
Pk:
120 Tests

Specifications

About this item

Mouse monoclonal antibody against human, monkey CD137 (ILA).

Dendritic cells
Nk cells
T cells

This mouse monoclonal antibody (clone 4B4-1) reacts with human and monkey CD137, a type I membrane protein and member of the TNF receptor superfamily. Following activation, it is expressed on multiple immune cells such as natural killer (NK), T, and dendritic cells. CD137 plays a role in cytokine activation, preventing activation-induced cell death and it also plays a role in promoting the activity of cytotoxic T cells. CD137 deficiency in humans has been hypothesized to inhibit differentiation and function of T cells; CD137-deficient mice have been recorded to have impaired T cell cytotoxicity, proliferation, and survival. As an immune stimulator, CD137 can influence the tumor microenvironment by increasing the cytotoxicity of T and NK cells as well as their ability to infiltrate tumors. For these reasons, CD137 represents a strong candidate for cancer immunotherapy. Use this monoclonal antibody in applications requiring detection of CD137, such as flow cytometry (FC).

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD137 (ILA)
Clonality: Monoclonal
Clone: 4B4-1
Conjugation: PE
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human;Monkey