Anti-CD105 Mouse Monoclonal Antibody [clone: 43A3]

Catalog # STMC60039

Supplier: STEMCELL Technologies

Catalog # STMC60039

Supplier: STEMCELL Technologies

Specifications

Antigen name:
Endoglin
Antigen symbol:
CD105
Clonality:
Monoclonal
Clone:
43A3
Conjugation:
Unconjugated
Host:
Mouse
Isotype:
IgG1 kappa
Reactivity:
Human,
Mouse
Gene ID:
2022
Pk:
100 µG

Specifications

About this item

Mouse monoclonal IgG1 antibody against human, mouse CD105 (endoglin), unconjugated.

Hematopoietic stem
Progenitor cells
Mesenchymal stem
Progenitor cells

The 43A3 antibody reacts with CD105 (endoglin), an ~180 kDa cell surface glycoprotein which is a disulfide-bonded homodimer of ~90 kDa type I transmembrane subunits. CD105 is a component of the TGF-β receptor complex and is expressed by vascular endothelial smooth muscle cells, syncytiotrophoblasts of placenta and activated macrophages, and at relatively low levels by stromal fibroblasts. Its expression is also observed in some types of tumors, and levels are up-regulated on the endothelium during angiogenesis. In concert with signaling receptors, CD105 binds to TGF-β1 and TGF-β3 with high affinity, but does not bind TGF-β2. Other ligands reportedly include Activin A, BMP-2, and BMP-7. CD105 has important roles in angiogenesis, cardiovascular development, and vascular remodeling, and the protein serves a regulatory role in cytoskeletal reorganization by modulating the sites of focal adhesion and cellular migration. Certain mutations in CD105 result in the autosomal dominant disorder hereditary hemorrhagic telangiectasia. This antibody clone has been verified for labeling human mesenchymal cells grown in MesenCult™ Proliferation Kit (Human; Catalog #05411) and MesenCult™-XF Medium (Catalog #05420).

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD105
Clonality: Monoclonal
Clone: 43A3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human, Mouse