Specifications
- Antibody type:Primary
- Antigen symbol:CHOP
- Clonality:Monoclonal
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG2b
- Western blot:Yes
- Seq:02
- Form:Liquid. In PBS containing 1 mg/ml BSA and 0,05% sodium azide
- Concentration:1 mg/ml
- Size:100 µg
- Pk:100 µG
Specifications
About this item
CHOP is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP α and β. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP-CHOP dimer gains binding activity to other non-classical C/EBP stress related targets.
Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of CHOP inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane.
- For Immunocytochemistry, Immunoprecipitation, Western Blot
Recognizes an N-terminal epitope of human and mouse CHOP. Detects a band of ~31kDa by Western blot.
Type: Primary
Antigen: CHOP
Clonality: Monoclonal
Clone:
Conjugation:
Epitope:
Host: Mouse
Isotype:
Reactivity: